CBD and Parkinsons
We developed our CBD to help with insomnia and broken sleep. And we noticed that our customers are using our CBD to treat anxiety and stress or CBD and the menopause.
However, we are contacted all the time by customers looking for information on CBD and Parkinson’s. I am always nervous commenting on this as I simply don’t know much about it, however over the weekend, I decided to do a little bit of online research into CBD and Parkinson’s.
Parkinson’s is a terrible ailment which I really hope we find a cure for. It affects an estimated 10 million people worldwide and in the UK is the second most common neurological disorder. Those diagnosed are usually over 50 years old with men being one-and-a-half times more to be diagnosed then women.
Parkinsons, by affecting motor ability significantly reduces a patient’s quality of life and can render a person unable to care for themselves.
Parkinson’s Disease impacts motor function by the degradation of of 60-80% of dopamine-producing neurons. As dopaminergic neurons degrade the brain unable to make dopamine and patients experience tremor of the hands, arms, legs or jaw; muscle rigidity or stiffness of the limbs. Additional symptoms include decreased facial expressions, dementia or confusion, fatigue, sleep disturbances, depression, constipation, cognitive changes, fear, anxiety, and urinary problems.
Non-motor symptoms occur for years before the disease progresses to the brain and Parkinson’s is actually a multi-system disorder, not just a neurological ailment, which develops over a long period of time. According to the Parkinon’s society, motor symptoms of PD only begin to manifest when most of the brain’s dopamine-producing cells are already damaged.
Early stage diagnosis may result in a better chance of slowing disease progression. The most common approach to treating PD is with oral intake of L-dopa but the long term taking of L-dopa can also exacerbate Parkinson’s.
The first account of using cannabis to treat possible Parkinson’s is in 1888. In his Manual of Diseases of the Nervous System, Grower noted that oral consumption of an “Indian hemp” extract quieted tremors temporarily, and after a heavy use the patient’s tremors nearly ceased.
Anecdotally we are aware of a number of individuals who have had some success using Parkinson’s to treat their tremors. However due to prohibition the available studies on CBD and Parkion’s are few and far between.
The only major study we were able to find indicated CBD may be able to asset in preventing Parkinson’s rather than reducing its symptoms.
“In respect to PD, although the pre-clinical studies are promising, the few studies with patients failed to detect improvement of the motor symptoms after treatment with CBD. There is a significant difference between the clinical and pre-clinical PD studies. In animals, the beneficial effects are seen when CBD is administered prior to or immediately after the manipulation that induces the PD-like symptoms. ….These data suggest that CBD's might have a preventive role rather than a therapeutic one in PD.”
For more information and lots of science we recommend this paper